FEATURED | July 2026
SIM4FLOW Selected for Nearly €0.5M EIC Pre-Accelerator Funding
Advancing IRIS toward clinical validation, technology maturity and international scale-up.
Date | News | Importance |
|---|---|---|
July2026 | Selected for nearly €0.5M EIC Pre-Accelerator funding | ⭐ Major company milestone |
March 2026 | Successful PINNs Proof of Concept | 🔬 Technology milestone |
2025 | IRIS advances toward clinical evaluation and user validation | 🏥 Clinical milestone |
2024 | €120k RIF Pre-Seed funding secured | 💶 Funding milestone |
Discover the latest developments, technological breakthroughs and funding milestones driving SIM4FLOW and IRIS forward.
SIM4FLOW Selected for Nearly €0.5 Million EIC Pre-Accelerator Funding to Advance IRIS
SIM4FLOW is proud to announce a major milestone in its journey to transform intracranial aneurysm management through artificial intelligence: the company has been selected for nearly €0.5 million in funding under the highly competitive European Innovation Council (EIC) Pre-Accelerator programme.
The EIC Pre-Accelerator is a European programme designed to support high-potential early-stage deep-tech companies in Horizon Europe widening countries by advancing their technology, strengthening business and investment readiness, and preparing them for future scale-up. The 2025 call supported selected companies with grants of up to €500,000. (European Innovation Council)
For SIM4FLOW, this achievement represents a significant step forward for IRIS — the Intracranial Rupture Intelligence System — and follows the company’s successful development of its technology through earlier research and innovation funding.
From €120k Pre-Seed to European Deep-Tech Funding
The EIC achievement builds on SIM4FLOW’s earlier success in securing €120,000 from the competitive Pre-Seed (0823) call of the Research and Innovation Foundation (RIF).
The RIF funding provided an important foundation for the development of IRIS, supporting the company’s team, technology development and transition from research innovation toward a scalable AI-powered healthcare solution.
The successful EIC Pre-Accelerator application now marks the next major stage in this development journey.
With the support of the EIC, SIM4FLOW will focus on advancing IRIS toward higher technological and clinical maturity, strengthening its validation and user evidence, and preparing the company for future investment and international commercialisation.
Advancing IRIS Toward Clinical Impact
IRIS is SIM4FLOW’s cloud-based AI platform for personalised assessment of intracranial aneurysm rupture risk.
The platform combines medical imaging, computational haemodynamics, machine learning and explainable AI to transform complex patient-specific information into interpretable insights that can support clinicians in the assessment and management of intracranial aneurysms.
Through the EIC-supported programme, SIM4FLOW will advance IRIS across several critical areas:
- Technology development and validation — further advancing the AI, computational and software components of IRIS.
- Physics-informed AI — incorporating advanced approaches that combine data-driven learning with physical knowledge of cardiovascular flow.
- Clinical evaluation and user validation — evaluating the platform with clinical users and generating evidence for its usability and potential clinical value.
- Explainable and trustworthy AI — strengthening the transparency and interpretability of AI-generated risk assessments.
- Platform maturity — progressing IRIS toward a robust, scalable and clinically oriented software platform.
- Business and investment readiness — strengthening SIM4FLOW’s commercial strategy and positioning the company for future private investment and follow-on European funding.
A Major Step for SIM4FLOW
Being selected for the EIC Pre-Accelerator is an important recognition of the innovation and potential of SIM4FLOW’s technology.
The programme is specifically designed to help promising European deep-tech companies move from technology validation toward greater technological, business and investment readiness, with a pathway toward future EIC Accelerator funding and other sources of scale-up investment. (European Innovation Council)
For SIM4FLOW, the next phase will focus on converting the technological potential of IRIS into clinically validated, trustworthy and scalable healthcare technology.
“This is a major milestone for SIM4FLOW and for IRIS. The EIC Pre-Accelerator gives us the opportunity to take the technology to the next level — strengthening its clinical validation, advancing our AI capabilities and preparing the company for international scale-up. We are excited to move from technology development toward real-world clinical impact.”
Dr. Nikolas Aristokleous
Founder & CEO, SIM4FLOW
The Next Chapter of IRIS
The EIC Pre-Accelerator represents another important step in SIM4FLOW’s long-term vision: to develop advanced computational and AI technologies that enable more personalised, evidence-based and transparent management of intracranial aneurysms.
SIM4FLOW is now working through the grant preparation and agreement process, ahead of the formal commencement of the EIC-supported project.
The company looks forward to working with the European Innovation Council and its partners to bring IRIS closer to clinical adoption and international impact.
From research. To innovation. To clinical impact.
SIM4FLOW Successfully Demonstrates Physics-Informed AI for Cardiovascular Flow Modelling
March 2026
SIM4FLOW has successfully demonstrated a Proof of Concept (PoC) using Physics-Informed Neural Networks (PINNs), marking an important technological milestone in the development of its next-generation computational and AI capabilities.
The successful PoC demonstrates the potential of combining deep learning with the underlying physics of cardiovascular blood flow, providing a promising pathway toward faster and more efficient patient-specific computational modelling.
Combining AI with Cardiovascular Physics
Traditional computational fluid dynamics can provide highly detailed information about blood flow and haemodynamics but can require substantial computational resources and time.
PINNs offer an alternative approach by incorporating governing physical laws directly into the learning process. This allows neural networks to learn solutions while respecting the underlying physics of the cardiovascular system.
For SIM4FLOW, this technology has significant potential for accelerating patient-specific haemodynamic analysis and supporting the development of advanced digital and AI-based tools for intracranial aneurysm management.
From Proof of Concept to IRIS-VISTA
The successful PINNs PoC represents an important step in SIM4FLOW’s technology roadmap and contributes to the company’s broader objective of combining:
- Medical imaging
- Computational fluid dynamics
- Physics-informed machine learning
- Explainable artificial intelligence
- Patient-specific digital modelling
These technologies form part of SIM4FLOW’s ongoing development strategy for IRIS, its AI-powered platform for intracranial aneurysm risk assessment.
The results also provide a strong technical foundation for the next phase of development under the company’s EIC Pre-Accelerator programme.
Towards Faster and More Scalable Patient-Specific Modelling
SIM4FLOW’s long-term objective is to reduce the computational barriers associated with advanced patient-specific haemodynamic modelling while maintaining clinically meaningful information.
The successful PoC demonstrates the potential of physics-informed AI to become an important component of this vision.
This milestone represents another step toward SIM4FLOW’s goal of developing trustworthy, explainable and computationally efficient AI technologies for personalised cardiovascular care.
SIM4FLOW Secures €120,000 RIF Pre-Seed Funding to Accelerate Development of IRIS
October 2024
SIM4FLOW secured €120,000 in funding through the competitive Pre-Seed (0823) call of the Research and Innovation Foundation (RIF) to accelerate the development of IRIS, its AI-powered platform for intracranial aneurysm risk assessment.
The funding represented an important early milestone for SIM4FLOW, providing the resources required to strengthen the company’s development team, advance the IRIS technology and establish the foundations for future clinical validation and commercialisation.
Building IRIS
IRIS — the Intracranial Rupture Intelligence System — is being developed to support personalised assessment of intracranial aneurysm rupture risk.
The platform combines medical imaging, artificial intelligence, computational modelling and explainable AI to provide patient-specific insights that can support clinical decision-making.
From Early Innovation to Deep-Tech Scale-Up
The RIF Pre-Seed funding enabled SIM4FLOW to accelerate the transition of IRIS from research and prototype development toward a more mature technology platform.
This early investment laid an important foundation for the subsequent technological advances, validation activities and international funding opportunities pursued by SIM4FLOW.
The company’s progress has since culminated in its selection for nearly €0.5 million of EIC Pre-Accelerator funding, marking the next stage in the development and scale-up of IRIS.
SIM4FLOW remains focused on its mission to transform intracranial aneurysm management through advanced, explainable and clinically meaningful AI.
"We are thrilled to secure this funding, which will enable us to accelerate the development of IRIS and bring it to even more healthcare providers worldwide. Our vision is to transform the management of intracranial aneurysms, and this investment brings us one step closer to realizing that goal."
Sim4Flow is excited about the future of aneurysm management and the potential of IRIS to transform patient care. With the support of this new funding, we are committed to accelerating the development and deployment of IRIS, making a significant impact on the lives of patients with intracranial aneurysms.